AdministratorWhat is the mechanism of action of Doxercalciferol?
Mechanism of Action They act directly on bone cells (osteoblasts) to stimulate skeletal growth, and on the parathyroid glands to suppress PTH synthesis and secretion. These functions are mediated by the interaction of these biologically active metabolites with specific receptor proteins in the various target tissues.
What is Doxercalciferol used for?
Doxercalciferol injection is used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone [PTH; a natural substance needed to control the amount of calcium in the blood] in people receiving dialysis (medical treatment to clean the blood when the kidneys are not …
What is Hectorol used for in dialysis?
This medication is used to treat people with serious kidney disease on dialysis who have high levels of a certain substance (parathyroid hormone-PTH), which your body normally makes. High PTH levels affect the balance of other minerals in your body (calcium and phosphorus) and may cause weak bones.
Is Hectorol active vitamin D?
Hectorol is a synthetic vitamin D2 analog that gets converted to a biologically active form of vitamin D2 in vivo, without the involvement of the kidneys, to help regulate iPTH serum levels in patients with CKD.
What does hyperparathyroidism cause?
In primary hyperparathyroidism, one or more of the parathyroid glands is overactive. As a result, the gland makes too much parathyroid hormone (PTH). Too much PTH causes calcium levels in your blood to rise too high, which can lead to health problems such as bone thinning and kidney stones.
Is parathyroid a hormone?
Parathyroid hormone (PTH) is a hormone your parathyroid glands release to control calcium levels in your blood. It also controls phosphorus and vitamin D levels. If your body has too much or too little parathyroid hormone, it can cause symptoms related to abnormal blood calcium levels.
Does hectorol increase phosphorus?
It works by decreasing PTH levels and increasing calcium/phosphorus levels in the body.
What is Glucophage drug used for?
It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
Does Hectorol increase phosphorus?
When is Hectorol given during dialysis?
Initiate HECTOROL injection at a dose of 4 mcg given by bolus intravenous administration three times weekly at the end of dialysis (no more frequently than every other day).
Does Hectorol lower phosphorus?
By taking Hectorol, you are helping to lower your PTH levels and maintain the right balance of calcium and phosphorus in your body.
Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25- (OH)2D2), a naturally occurring, biologically active form of vitamin D2.
Who is the developer of Doxercalciferol?
R.A.U. and C.W.B. are paid consultants of Bone Care International Inc., the developer of doxercalciferol; J.C.K. and L.W.L. are employees and C.W.B. was an employee of Bone Care International. C.W.B. holds stock in Bone Care International.
How is Doxercalciferol converted to vitamin D?
In the liver, doxercalciferol is converted to its biologically active vitamin D metabolites, which control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton.
Is Doxercalciferol a hormone or a steroid?
It is a vitamin D and a hydroxy seco-steroid. Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25- (OH)2D2), a naturally occurring, biologically active form of vitamin D2.