What is cp50?

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A symbol for the measure of intravenous anesthetic potency, specifically the concentration of the agent in the blood that will prevent movement after a skin incision in half the patients to whom the agent is given.

What is the antidote of propofol?

Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers. Anesthesiology.

What is propofol induction?

Propofol is an intravenous anesthetic used for procedural sedation, during monitored anesthesia care, or as an induction agent for general anesthesia. It may be administered as a bolus or an infusion, or some combination of the two.

How do you titrate propofol?

Initial dose: 5 mcg/kg/min IV infusion for at least 5 minutes.
Titration: can be titrated in 5-10mcg/kg/min increments to achieve the desired level of sedation, up to a maximum dose of 80mcg/kg/min.

What is a MAC of Propofol?

MAC anesthesia — also called monitored anesthesia care or MAC, is a type of anesthesia service during which a patient is typically still aware, but very relaxed.

What happens if you give propofol too fast?

A rapid bolus injection can result in undesirable cardiorespiratory depression including hypotension, apnea, airway obstruction, and oxygen desaturation.

How can propofol cause death?

Propofol abuse and recreational use often lead to death because of the rapid onset of unconsciousness and apnea following injection (3).

Do you need to be intubated for propofol?

Conclusion: Propofol-based sedation without endotracheal intubation is safe for ESD procedures in the esophagus and stomach with low anesthesia-related complication rates and short hospital stay.

Why does propofol make you sleep?

The researchers found that propofol restricted the movement of a key protein — syntaxin1A — that’s required at the synapses of all neurons. That lowers communication between brain neurons.

How do I start propofol infusion?

For induction of anaesthesia Propofol should be titrated (approximately 20 – 40 mg propofol every 10 seconds) against the response of the patient until clinical signs show the onset of anaesthesia. Most adult patients aged less than 55 years are likely to require 1.5 to 2.5 mg propofol/kg body weight.

How is propofol infusion calculated?

Calculation of rate (ml/hr) = (mg/kg/hr) x 0.1 (Note: changes in the rate of administration should be made slowly (>5 minutes) in order to minimize hypotension and avoid acute overdosage.

What is the difference between Mac anesthesia and conscious sedation?

Monitored Anesthesia Care (MAC), also known as conscious sedation or twilight sleep, is a type of sedation that is administered through an IV to make a patient sleepy and calm during a procedure. The patient is typically awake, but groggy, and are able to follow instructions as needed.